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THORNE PharmaGABA-250 - GABA Supplement - 250 mg Natural Source Gamma-Aminobutyric Acid - Promotes a Calm, Relaxed, Focused State of Mind - 60 Capsules

4.4 4.4 out of 5 stars 564 ratings

$52.83 $0.88 per Count
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Purchase options and add-ons

Brand THORNE
Flavor natural
Primary Supplement Type natural GABA
Unit Count 60.00 Count
Item Form Capsule
Item dimensions L x W x H 2.09 x 2.09 x 3.72 inches
Product Benefits Sleep Support
Age Range (Description) Adult
Package Information Bottle
Number of Items 1

About this item

  • Natural Source: GABA is an important brain chemical that acts like a brake during times of runaway stress*
  • Calm: Promotes a calm, relaxed, focused state of mind*
  • Sleep: Supports restful sleep*
  • Clinical Research: Natural-source GABA outperforms synthetic GABA in clinical studies
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish

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Product Description

PharmaGABA-250

PharmaGABA features a natural source of the inhibitory neurotransmitter – GABA. GABA supports restful sleep, acts like a “brake” on stress, and provides a focused state of mind.*

Well-Researched Benefits

Clinical studied

Purest Ingredients

Convenient Protocol

Well-Researched Benefits

Clinical studies show the natural form of GABA in Thorne's PharmaGABA decreases the brain's stress-related beta waves and increases the production of its alpha-waves, creating a sense of physical relaxation while maintaining mental focus.* Other studies show reduced pupil diameter, heart rate, and two natural biomarkers of stress – salivary cortisol and chromogranin A – all signs of relaxation.*

Clinically Studied

In a recent study of the effect of GABA supplementation on muscle mass, 21 males, average age 39, who did not exercise regularly, were given 10 grams of whey protein or 10 grams of whey protein plus 100 mg of PharmaGABA daily for 12 weeks. Both groups participated in twice weekly 60-minute strength training sessions that consisted of leg presses, leg extensions, leg curls, chest presses, and pull-downs. Statistically significant increases in total body lean muscle mass was observed in the whey protein-plus-PharmaGABA group but not in the whey-only group.*

Purest Ingredients

The natural GABA in Thorne's PharmaGABA suite is produced via a fermentation process that utilizes Lactobacillus hilgardii, the same bacteria strain used to ferment cabbage in the preparation of the traditional Korean dish, kimchi.

Convenient Protocol

PharmaGABA-250 offers 250 mg of natural GABA per capsule and is non-habit forming.

sleep

Sleep isn’t just about “getting a good night’s rest.” New information regularly emerges about sleep’s importance to disease prevention, cognitive function, mood, athletic performance, and even maintaining a healthy weight. The adverse health conditions that can occur with chronically poor sleep include diabetes, obesity, infertility, heart disease, sleep apnea, and more. Unfortunately, even though we might be eating right, exercising, and making healthy decisions, we might be neglecting our sleep. In fact, more than 40 percent of U.S. adults don’t get the ideal amount of sleep each night.

One great strategy to get a good night’s sleep is to supplement with nutrients that support sleep’s natural triggers and reduce stress in the body.* Thorne offers supplements that support healthy sleep.*

Innovative solutions

When the highest standards have been met, Thorne creates higher ones.

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Sourcing Exceptional Ingredients

We develop better standards for higher quality ingredients. Thorne cares deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility. Better ingredients means better potency, absorption, and digestibility - and ultimately better health.

Manufacturing the Right Way

We manufacture our own products to ensure full supply chain transparency. For more than 30 years, we have invested in clean manufacturing practices. We refuse to use ingredients that can inhibit absorption. We perform our final production in the United States. Our Charleston, SC facility is third-party certified.

Four Rounds of Testing

We run four rounds of testing for each of our products. We have invested in two state-of-the-art in-house laboratories that allow us to conduct four rounds of testing, while most competitors test only one or two times. We test our raw materials, in-process batches, finish products, and product stability for each product.

Thinking Sustainably

We're thinking sustainably to protect our environment. We believe the environment should never be compromised for the sake of business gain. At Thorne, we believe that doing our part to protect the environment and its most valuable resources goes hand in hand with our product quality standards.

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 2.09 x 2.09 x 3.72 inches; 2.12 ounces
  • Item model number ‏ : ‎ SP662-R
  • Date First Available ‏ : ‎ January 1, 2011
  • Manufacturer ‏ : ‎ Thorne Research
  • ASIN ‏ : ‎ B005P0UCZS
  • Customer Reviews:
    4.4 4.4 out of 5 stars 564 ratings

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This Item
THORNE PharmaGABA-250 - GABA Supplement - 250 mg Natural Source Gamma-Aminobutyric Acid - Promotes a Calm, Relaxed, Focused State of Mind - 60 Capsules
THORNE PharmaGABA-250 - GABA Supplement - 250 mg Natural Source Gamma-Aminobutyric Acid - Promotes a Calm, Relaxed, Focused State of Mind - 60 Capsules
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Price$52.79$70.00-39% $8.56
List:$13.99
$22.05$38.00-50% $12.95
List:$25.99
Price Per Unit$0.88 / Count$0.39 / Count$0.09 / Count$0.12 / Count$0.42 / Count$0.06 / Count
Delivery
Get it as soon as Monday, May 20
Get it as soon as Sunday, May 19
Get it as soon as Sunday, May 19
Get it as soon as Sunday, May 19
Get it as soon as Sunday, May 19
Get it as soon as Sunday, May 19
Customer Ratings
Easy to swallow
4.3
4.6
4.3
4.3
4.0
4.3
Flavor
4.2
3.5
4.2
4.2
4.0
4.2
Value for money
2.7
3.6
4.5
4.2
4.0
4.5
Absorbency
3.9
4.5
4.5
Sold By
KING'S CORNER
Pattern.
Amazon.com
Health Chest
Pattern.
Amazon.com
keyword type
multiple-vitamin-mineral-combinations
multiple-vitamin-mineral-combinations
vitamin-b6
multiple-vitamin-mineral-combinations
omega-3-nutritional-supplements
vitamin-b6
form
Capsule
Capsule
Capsule
Capsule
Gelcap
Capsule
flavor
natural
Unflavored
Unflavored
Unflavored
Unflavored
Unflavored
size
60 Count (Pack of 1)
90 Count (Pack of 2)
100 Count (Pack of 1)
180 Count (Pack of 1)
90 Count (Pack of 1)
200 Count (Pack of 1)
weight
0.55 pounds
0.1 kilograms
0.1 pounds
0.2 kilograms
age range
Adult
Adult
Adult
Adult
Adult
Adult
product benefit
Sleep Support
Energy Management, Sleep Health Support, Metabolism Improvement, Antioxidant, Joint Health Support, Bone Health Support
Stress Relief
Hypoallergenic
Brain Health Support, Cardiovascular Support, Heart Health Support, Cholesterol Management, Inflammation Management, Bone & Joint Support
Brain Health Support

Important information

Safety Information

Allergy warning: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. This product also does not contain lactose, palmitic acid, or magnesium, calcium, or vegetable stearates. Pregnancy warning: If pregnant, nursing, or trying to conceive, consult your health-care practitioner before using this product. Interactions /Contraindications: There are no known adverse interactions or contraindications at the publication date.

Indications

Stress Support, Sleep Support

Ingredients

One Capsule Contains: Gamma-Aminobutyric Acid (GABA) 250 mg. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Magnesium Citrate, Calcium Laurate.

Directions

Take 1 capsule one to three times daily or as recommended by a health-care practitioner.

Legal Disclaimer

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Looking for specific info?

Customer reviews

4.4 out of 5 stars
4.4 out of 5
564 global ratings

Customers say

Customers like the quality and quantity of the nutritional supplement. They say it works great to calm the nervous system and helps them stay calm. However, some customers report negative side effects, including dizziness, spaciness, and headaches. Opinions are mixed on the value.

AI-generated from the text of customer reviews

30 customers mention30 positive0 negative

Customers say the product helps relieve anxiety and stress. They say it helps to calm the nervous system, and it helps them stay calm. Some say it eases withdrawal symptoms.

"...I woke up the next day a few minutes BEFORE my alarm. I felt refreshed, perfect...." Read more

"Very calming. Great to use if your tapering off of meditation. I will purchase again." Read more

"...I take PharmaGaba 3 times daily as recommended. It does not make me sleepy but rather just levels everything out...." Read more

"When added to magnesium at night, helping with sleep! great!" Read more

26 customers mention23 positive3 negative

Customers like the quality of the nutritional supplement. They say it works well, is of excellent quality, and is the best option on the market. Some say it's a natural alternative to Xanax.

"My research shows me that this is a high quality product. And I don't base that on widely varying reviews...." Read more

"Very calming. Great to use if your tapering off of meditation. I will purchase again." Read more

"...These quality assurance processes include microbiological analysis, testing for solvent residues, and screening for pesticides, heavy metals, and..." Read more

"...Out of lots of options on Amazon, this brand has consistently tested as the best option and I have used them for various things for a couple of..." Read more

10 customers mention3 positive7 negative

Customers have mixed opinions about the value of the nutritional supplement. Some say it's worth the cost, while others say it’s expensive and doesn't work.

"Low dose and expensive when compared to alternative products with same ingredients. This said; have to take 4-6x as much for efficacious dose." Read more

"...Works much better than other brands so is worth th cost." Read more

"...reaction to Thorne, I would not recommend it as it also comes at a substantial price." Read more

"Took it and felt an immediate calmness.Its quite expensive and I do wish it wasn't so high but this will be a future purchase, more like..." Read more

8 customers mention2 positive6 negative

Customers are dissatisfied with the pain relief provided by the nutritional supplement. They mention that it causes constant feelings of dizziness, spaciness, headaches, and vivid dreams. Some say that it makes them feel loopy and sick to their stomach.

"...that taking 250mg on an empty stomach in the morning gives me an uneasy feeling in about 10 minutes and subsides in about 20...." Read more

"...before bed and yes it helps me sleep however I’m groggy all day and restless. I feel like a zombie...." Read more

"...and aphasia will just be what they will be, but at least the pain is manageable. This is a godsend for me." Read more

"Probably good if I could keep taking it but it makes me feel loopy every time I try to take it." Read more

Great at stress relief
5 Stars
Great at stress relief
The Thorne PharmaGABA 250 seems to work as good as prescription medication for anxiety and stress. The results were noticeable after 2 days of taking the medication (taking 2 pills a day).
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Top reviews from the United States

Reviewed in the United States on July 13, 2022
I did a sleep/stress test and learned that my cortisol was upside down.

Low in the morning - so sluggish and can't get out of bed, even at 10 AM, I could only get up because I HAD TO.

High in the evening - laying in bed, almost like I have a panic attack - so alert, I can't sleep.

I'm taking a few supplements now and altering my diet and lifestyle to reduce my cortisol levels. I want them high in the morning, so I can spring out of bed and low in the evening to lay down and rest.

This PharmaGABA-250 is one of the supplements I started taking with the guidance of a functional nutritionist after we saw my cortisol labs.

I can report that I noticed the effect of this supplement. I took it with a small glass of water about 30 minutes before bedtime. Fifteen minutes in, I started to feel very heavy - like how I feel when I'm sleepy. I did my bedtime routine - put on PJs, washed my face, brushed my teeth, etc., and got into bed.

I woke up the next day a few minutes BEFORE my alarm. I felt refreshed, perfect.

I've been taking this every night and have had great success, except one night when I had some sugar close to bedtime (I had cocoa), that disrupted the experience. So, GABA helps a lot, but diet also impacts me.

One dose-related caution I would use is that my partner wanted to try this supplement to help him sleep when stressed about work. He couldn't stop thinking about work. He took one pill (same as I do), and he slept. He felt very heavy the next day and struggled with work in the morning, which was the exact opposite effect he wanted. He might benefit from Thorne's lower (100mg) dose. We've ordered it, but he hasn't tried it yet. If you're not sure how much you need, I recommend starting with the lower dose because you can always take more of them if you find you need them.
56 people found this helpful
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Reviewed in the United States on March 14, 2022
My research shows me that this is a high quality product. And I don't base that on widely varying reviews.
If GABA is actually what you need, then this supplement should help. If it is not what your particular situation requires, it will probably do nothing and you could then end your GABA supplementation experiment.
My experience is that taking 250mg on an empty stomach in the morning gives me an uneasy feeling in about 10 minutes and subsides in about 20. I cut back to 100mg and don't get that feeling.
I don't take it later in the day, as GABA can increase your mental focus and keep you awake.
I was on Xanax VERY INFREQUENTLY in the past and GABA supplementation has replaced that medication for me.
You may also consider a HIGH QUALITY vitamin B supplement in your supplementation experiments.
I recommend this product based only on my personal experience. Your physiology may give you a totally different experience.
34 people found this helpful
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Reviewed in the United States on October 30, 2023
I have used this brand for Gaba 250 along with other supplements. Works much better than other brands so is worth th cost.
2 people found this helpful
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Reviewed in the United States on November 25, 2017
Very calming. Great to use if your tapering off of meditation. I will purchase again.
13 people found this helpful
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Reviewed in the United States on June 14, 2022
My physician recommended this for my anxiety. I had tried many other supplements on my own that all promised to calm, relax, help focus, help sleep, etc. I have struggled with insomnia, anxiety and panic attacks for the past 4 years. I am currently taking Xanax to help manage my symptoms but I do not want to stay on Xanax the rest of my life. This is the only product that I have found that actually works. It keeps the anxiety from getting out of control. I can usually just breathe through it now. And this supplement has allowed me to start dosing back on Xanax. I take PharmaGaba 3 times daily as recommended. It does not make me sleepy but rather just levels everything out. It does not feel like I took a Xanax which you definitely feel the affects of but rather I noticed that I just felt calm throughout the day. No ups and downs, no jitters, no racing heart, no fight or flight feeling. It really has given me hope that I will be able to get off of Xanax and start to manage my anxiety in a healthier way.
59 people found this helpful
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Reviewed in the United States on February 17, 2024
This is the best gaba supplement I have ever tried
2 people found this helpful
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Reviewed in the United States on December 22, 2023
When added to magnesium at night, helping with sleep! great!
2 people found this helpful
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Reviewed in the United States on January 19, 2024
Low dose and expensive when compared to alternative products with same ingredients. This said; have to take 4-6x as much for efficacious dose.

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